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M9650441.TXT
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1996-03-09
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Document 0441
DOCN M9650441
TI Dietary determinants of a non-progressive spastic paraparesis (Konzo): a
case-referent study in a high incidence area of Zaire.
DT 9605
AU Tylleskar T; Banea M; Bikangi N; Nahimana G; Persson LA; Rosling H;
Department of Pediatrics, University Hospital, Uppsala, Sweden.
SO Int J Epidemiol. 1995 Oct;24(5):949-56. Unique Identifier : AIDSLINE
MED/96128723
AB BACKGROUND. Konzo is an upper motor neuron disease in Africa,
characterized by an abrupt onset of a permanent but non-progressive
spastic paraparesis. It is named after the local designation in the
first report from Zaire. Konzo has been attributed to a metabolic insult
from the combined effect of high cyanide and low sulphur intake from
several weeks of exclusive consumption of insufficiently processed
bitter cassava roots. METHODS. The association between insufficient
soaking of cassava roots and konzo is assessed in a matched
case-referent study with multivariate conditional logistic regression
including 57 case-referent pairs from a rural high incidence community
of Zaire. RESULTS. In the multivariate analysis short processing of
cassava in the form of only 2 nights soaking yielded an odds ratio of
11.0 (95% confidence interval 1.7-73) when controlling for
poverty-related factors and diet. We also show a dose-response
relationship for insufficient cassava soaking, both unadjusted and
adjusted for potential confounders. CONCLUSIONS. This study supports a
causal relationship between insufficient processing of bitter cassava
and konzo.
DE Adolescence Adult Age of Onset Aged Case-Control Studies
Cassava/*POISONING Child Child, Preschool *Cookery *Diet Female
Human Logistic Models Male Middle Age Multivariate Analysis
Paraparesis, Tropical Spastic/EPIDEMIOLOGY/*ETIOLOGY Rural Health
Seasons Socioeconomic Factors Support, Non-U.S. Gov't
Zaire/EPIDEMIOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).